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Andrew Daugulis

Faculty - Andrew J. Daugulis, Ph.D., P.Eng.

Professor of Chemical Engineering, Biology, and Microbiology and Immunology.
Queen's Research Chair in Biochemical and Cell Culture Engineering

Tel: (613) 533-2784
Fax: (613) 533-6637
Email: andrew.daugulis@chee.queensu.ca
Office: Dupuis Hall 316


Publications

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Journal Publications

Yeom, S.H., Daugulis, A.J. and Nielsen, D.R., "Estimating The Cellular Maintenance Coefficient and Its Use in the Design of Two-Phase Partitioning Bioscrubbers," Bioproc Biosys Eng In Press, 2010.

Littlejohns, J.V., McAuley, K.B. and Daugulis, A.J., "Model for a Solid-Liquid Stirred Tank Two-Phase Partitioning Bioscrubber for the Treatment of BTEX," Journal of Hazardous Materials In Press, 2010.

Gao, F. and Daugulis, A.J., "Polymer-Solute Interactions In Solid-Liquid Two-Phase Partitioning Bioreactors," J. Chem. Technol. Biotechnol. In Press, 2009.

Littlejohns, J.V., McAuley, K.B. and Daugulis, A.J., "Model for a Solid-Liquid Airlift Two-Phase Partitioning Bioscrubber for the Treatment of BTEX," J. Chem. Technol. Biotechnol. In Press, 2009.

Tomei, M.C., Annesini, M.C., Prpich, G.P. and Daugulis, A.J., "Biodegradation of 4-Nitrophenol in a Two Phase System Operating with Polymers As the Partitioning Phase," Env. Sci. & Technol. 43, 7105-7110, 2009 [More information].

Littlejohns, J.V. and Daugulis, A.J., "Oxygen Mass Transfer and Hydrodynamics in a Multi-Phase Airlift Bioscrubber System," Chem Eng. Sci. 64, 4171-4177, 2009 [More information].

Gao, F. and Daugulis, A.J., "Bioproduction of the aroma compound 2-phenylethanol in a solid-liquid Two-Phase Partitioning Bioreactor system by Kluyveromyces marxianus," Biotechnol. Bioeng. 104, 332-339, 2009 [More information].

Isaza, P.A. and Daugulis, A.J., "Ultrasonically Enhanced Delivery and Degradation of PAHs in a Polymer-Liquid Partitioning System by a Microbial Consortium," Biotechnol. Bioeng. 104, 91-101, 2009 [More information].

Littlejohns, J.V and Daugulis, A.J., "A Two-Phase Partitioning Airlift Bioreactor for the Treatment of BTEX Contaminated Gases," Biotechnol. Bioeng. 103, 6, 1077-1086, 2009 [More information].

Littlejohns, J.V. and Daugulis, A.J., "Response of a Solid-Liquid Two-Phase Partitioning Bioreactor to Transient BTEX Loadings," Chemosphere 73, 1453-1460, 2008 [More information].

Tomei, M.C., Annesini, M.C., Rita, S. and Daugulis, A.J., "Biodegradation of 4-nitrophenol in a Two Phase Sequencing Batch Reactor: Concept Demonstration, Kinetics and Modelling," Appl. Microbiol. Biotechnol. 80, 1105-1112, 2008 [More information].

Rehmann, L., Prpich, G.P. and Daugulis, A.J., "Bioremediation of PAH Contaminated Soils: Application of a Solid-Liquid Two-Phase Partitioning Bioreactor," Chemosphere 73, 798-804, 2008 [More information].

Littlejohns, J.V. and Daugulis, A.J., "Kinetics and Interactions of BTEX Compounds During Degradation by a Bacterial Consortium," Process Biochem 43, 1068-1076, 2008 [More information].

Morrish, J.L.E. and Daugulis, A.J., "Improved Reactor Performance and Operability in the Biotransformation of Carveol to Carvone Using a Solid-liquid Two Phase Partitioning Bioreactor," Biotechnol. Bioeng. 101, 946-956, 2008 [More information].

Morrish, J.L.E., Brennan, E., Dry, H. and Daugulis, A.J., "Enhanced Bioproduction of Carvone in a Two Liquid Phase Partitioning Bioreactor with a Highly Hydrophobic Biocatalyst," Biotechnol. Bioeng. 101, 768-775, 2008 [More information].

Prpich, G.P., Rehmann, L. and Daugulis, A.J., "On The Use, and Re-Use, of Polymers for the Treatment of Hydrocarbon Contaminated Water Via a Solid-Liquid Partitioning Bioreactor," Biotechnol. Prog. 24, 839-844, 2008 [More information].

Daugulis, A.J. and Boudreau, N.G., "Solid-Liquid Two-Phase Partitioning Bioreactors for the Treatment of Gas-Phase VOCs by a Microbial Consortium," Biotechnol Letters 30, 1583-1587, 2008 [More information].

Daugulis, A.J., "A Survey Of Bioengineering Research In Canada-2007," Biotechnol. Prog. 24, 795-806, 2008 [More information].

Rehmann, R. and Daugulis, A.J., "Biodegradation of PCBs in Two-Phase Partitioning Bioreactors Following Solid Extraction from Soil," Biotechnol. Bioeng. 99, 1273-1280, 2008 [More information].

Morrish, J.L.E. and Daugulis, A.J., "Inhibitory effects of substrate and product on the carvone biotransformation activity of Rhodococcus erythropolis ," Biotechnol. Letters 30, 1245-1250, 2008 [More information].

McMahon, M.J.L. and Daugulis, A.J., "Enhancement of Biogenic Sulfide Production in a Packed Bed Bioreactor via Critical Inoculum Design and Carrier Material Selection," Biotechnol. Bioeng. 100, 855-863, 2008 [More information].

McMahon, M.J.L. and Daugulis, A.J., "Gas Phase H2S Product Recovery In A Packed Bed Bioreactor With Immobilized Sulfate Reducing Bacteria ," Biotechnol. Letters 30, 467-473, 2008 [More information].

Rehmann, L. and Daugulis, A.J., "Enhancement of PCB Degradation by Burkholderia xenovorans LB400 in Biphasic Systems by Manipulating Culture Conditions," Biotechnol. Bioeng. 99, 3, 521-258, 2008 [More information].

Rehmann, L. and Daugulis, A.J, "Bioavailability of PCBs in Biphasic Bioreactors," Biochem Eng J 38, 219-225, 2008 [More information].

Rehmann, L. and Daugulis, A.J., "Polymer Selection for Biphenyl Degradation in a Solid-Liquid Two-Phase Partitioning Bioreactor," Biotechnol. Prog. 23, 4, 814-819, 2007 [More information].

Prpich, G.P and Daugulis, A.J., "A Novel Solid-Liquid Two-Phase Partitioning Bioreactor for the Enhanced Bioproduction of 3-methylcatechol," Biotechnol. Bioeng. 98, 1008-1016, 2007 [More information].

Rehmann, L. and Daugulis, A.J., "Biodegradation of Biphenyl in a Solid-Liquid Two-Phase Partitioning Bioreactor," Biochem Eng J 36, 195-201, 2007 [More information].

Nielsen, D.R., Daugulis, A.J. and McLellan, P.J., "Dynamic Simulation of Benzene Vapor Treatment by a Two-Phase Partitioning Bioscrubber. Part II: Model Calibration, Validation, and Predictions," Biochem Eng J 36, 250-261, 2007 [More information].

Nielsen, D.R., Daugulis, A.J. and McLellan, P.J., "Dynamic Simulation of Benzene Vapor Treatment by a Two-Phase Partitioning Bioscrubber. Part I: Model Development, Parameter Estimation, and Parametric Sensitivity," Biochem Eng J 36, 239-249, 2007 [More information].

Vandermeer, K.D. and Daugulis, A.J., "Enhanced Degradation of a Mixture of Polycyclic Aromatic Hydrocarbons by a Defined Microbial Consortium in a Two-Phase Partitioning Bioreactor," Biodegradation 18, 211-221, 2007 [More information].

Littlejohns, J.V. and Daugulis, A.J., "Oxygen Transfer in a Gas-Liquid System Containing Solids of Varying Oxygen Affinity," Chem Eng J 129, 67-74, 2007 [More information].

Prpich, G.P. and Daugulis, A.J., "Solvent Selection For Enhanced Bioproduction of 3-methylcatechol in a Two-Phase Partitioning Bioreactor," Biotechnol. Bioeng. 97, 536-543, 2007 [More information].

Eibes, G., M.T. Moreira, M.T., Feijoo, G, Daugulis, A.J., and Lema, J.M., "Operation Of A Two Phase Partitioning Bioreactor for the Degradation of Anthracene by the Enzyme Manganese Peroxidase," Chemosphere 66, 1744-1751, 2007 [More information].

Prpich, G.P., Adams, R.L., and Daugulis, A.J., "Ex situ bioremediation of phenol contaminated soil using polymer beads," Biotechnology Letters 28, 24, 2027-2031, 2006 [More information].

Nielsen, D.R., Sask, K.N., McLellan, P.J. and Daugulis, A.J., "Benzene Vapor Treatment Using a Two-Phase Partitioning Bioscrubber: An Improved Steady-State Protocol to Enhance Long-Term Operation," Bioproc. Biosyst. Eng. 29, 229-240, 2006 [More information].

Nielsen, D.R., McLellan, P.J. and Daugulis, A.J., "Direct estimation of the oxygen requirements of Achromobacter xylosoxidans for aerobic degradation of monoaromatic hydrocarbons (BTEX) in a bioscrubber," Biotechnol. Letters 28, 16, 1293-1298, 2006 [More information].

Prpich, G.P and Daugulis, A.J., "Biodegradation of a Phenolic Mixture in a Solid-Liquid Two Phase Partitioning Bioreactor," Appl. Microbiol. Biotechnol. 72, 607-615, 2006 [More information].

Boudreau, N.G. and Daugulis, A.J., "Transient Performance Of Two-Phase Partitioning Bioreactors Treating A Toluene Contaminated Gas Stream," Biotechnol Bioeng. 94, 3, 448-457, 2006 [More information].

Tyshenko, M.G., d'Anjou, M., Davies, P.L., Daugulis, A.J., and Walker, V.K., "Challenges In The Expression Of Disulfide Bonded, Threonine-Rich Antifreeze Proteins In Bacteria And Yeast," Protein Expression and Purification 47, 1, 152-161, 2006 [More information].

Rehmann L., and Daugulis, A.J., "Biphenyl degradation kinetics by Burkholderia xenovorans LB400 in two-phase partitioning bioreactors," Chemosphere 63, 6, 972-979, 2006 [More information].

Nielsen, D.R., Daugulis, A.J., and McLellan, P.J., "Transient Performance of a Two-Phase Partitioning Bioscrubber Treating a Benzene-Contaminated Gas Stream," Env. Sci Technol. 39, 8971-8977, 2005 [More information].

Nielsen, D.R., Daugulis, A.J. and McLellan, P.J., "A Restructured Framework for Modeling Oxygen Transfer in Two-Phase Partitioning Bioreactors," Biotechnol. Bioeng 91, 773-777, 2005 [More information].

Nielsen, D.R., Daugulis, A.J. and McLellan, P.J., "Quantifying Maintenance Requirements from the Steady-State Operation of a Two-Phase Partitioning Bioscrubber," Biotechnol. Bioeng 90, 248-258, 2005 [More information].

Baumann, M.D., Daugulis, A.J., and Jessop, P.G., "Phosphonium Ionic Liquids for Degradation of Phenol in a Two-Phase Partitioning Bioreactor," Appl. Microbiol. Biotechnol 67, 131-137, 2005 [More information].

Prpich, G.P. and Daugulis, A.J., "Enhanced Biodegradation of Phenol By a Microbial Consortium in a Solid-Liquid Two Phase Partitioning Bioreactor," Biodegradation 16, 329-339, 2005 [More information].

MacLeod C.T. and Daugulis, A.J., "Interfacial Effects in a Two-Phase Partitioning Bioreactor: Degradation of Polycyclic Aromatic Hydrocarbons (PAHs) by Hydrophobic Mycobacterium," Process Biochem 40, 1799-1805, 2005 [More information].

Prpich, G.P and Daugulis, A.J., "Polymer Development For Enhanced Delivery Of Phenol In A Solid-Liquid Two-Phase Partitioning Bioreactor," Biotechnol. Progr 20, 1725-1732, 2004 [More information].

Davidson, C.T. and Daugulis, A.J., "Addressing Biofilter Limitations: A Two-Phase Partitioning Bioreactor Process For The Treatment Of Benzene And Toluene Contaminated Gas Streams," Biodegradation 14, 415-421, 2003 [More information].

Amsden, B.G., Bochanysz, J., and Daugulis, A.J., "Degradation of Xenobiotics in a Partitioning Bioreactor in which the Partitioning Phase is a Polymer," Biotechnol. Bioeng 84, 399-405, 2003 [More information].

Daugulis, A.J., and McCracken, C.M., "Microbial Degradation of High and Low Molecular Weight Polyaromatic Hydrocarbons in a Two-Phase Partitioning Bioreactor by Two Strains of Sphingomonas sp.," Biotechnol. Letters 25, 1421-1424, 2003 [More information].

Daugulis. A.J. and Boudreau, N.G., "Removal and Destruction of High Concentrations Of Gaseous Toluene in a Two-Phase Partitioning Bioreactor by Alcaligenes xylosoxidans," Biotechnol. Letters 25, 1441-1444, 2003 [More information].

Daugulis, A.J., Amsden, B.G., Bochanysz, J. and Kayssi, A., "Delivery of Benzene to Alcaligenes xylosoxidans by Solid Polymers in a Two-Phase Partitioning Bioreactor," Biotechnol. Letters 25, (14), 1203-1207, 2003 [More information].

Nielsen, D.R., Daugulis, A.J. and McLellan, P.J., "A Novel Method of Simulating Oxygen Mass Transfer in Two-Phase Partitioning Bioreactors," Biotechnol.Bioeng 83, 735-742, 2003 [More information].

Davidson, C.T. and Daugulis, A.J., "The Treatment of Gaseous Benzene by Two-Phase Partitioning Bioreactors: A High Performance Alternative to the Use of Biofilters," Appl.Microbiol.Biotechnol 62, 297-301, 2003 [More information].

MacLeod, C.T. and Daugulis, A.J., "Biodegradation of Polycyclic Aromatic Hydrocarbons in a Two-Phase Partitioning Bioreactor in the Presence of a Bioavailable Solvent," Appl.Microbiol.Biotechnol 62, 291-296, 2003 [More information].

Pudge, I.B., Dubois, C. and Daugulis, A.J., "The Use of Enterobacter cloacae ATCC 43560 in the Development of a Two-Phase Partitioning Bioreactor for the Destruction of Hexahydro-1,3,5-trinitro-1,3,5-s-triazine (RDX)," J. Biotechnol 100, (1), 65-75, 2003 [More information].

Janikowski, T.B., Velicogna, D., Punt, M., and Daugulis, A.J., "Use of a Two-Phase Partitioning Bioreactor for Degrading Polycyclic Aromatic Hydrocarbons by a Sphingomonas sp.," Appl Microbiol Biotechnol 59, 368-376, 2002 [More information].

Vrionis, H., Kropinski, A.M.B. and Daugulis, A.J., "Enhancement Of A Two-Phase Partitioning Bioreactor System By Catalyst Modification: Demonstration Of Concept," Biotechnol. Bioeng 79, 587-594, 2002 [More information].

Daugulis, A.J. and Janikowski, T.B., "Scale-Up Performance of a Partitioning Bioreactor for the Degradation of Polyaromatic Hydrocarbons by Sphingomonas aromaticivorans," Biotechnol. Letters 24, (8), 591-594, 2002 [More information].

Vrionis, H., Kropinski, A.M.B. and Daugulis, A.J., "Strain Modification And Feed Strategies For Expanded Application Of A Two-Phase Partitioning Bioreactor To Phenol Degradation," Biotechnology Progress 18, (3), 458-464, 2002 [More information].

Vrionis, H.A., Daugulis, A.J. and Kropinski, A.M., "Identification And Characterization Of The Agmr Regulator Of Pseudomonas putida: Role In Alcohol Utilization," Appl.Microbiol.Biotechnol 58, 469-475, 2002 [More information].

Malinowski, J.J. and Daugulis, A.J., "An Effective Approach for Recovery of Methyl-substituted 1,3-Dioxane from Aqueous Media," Separation Science and Technology 37, (11), 2659-2667, 2002 [More information].

Daugulis, A.J., "Two-Phase Partitioning Bioreactors: A New Technology Platform for Destroying Xenobiotics," Trends in Biotechnology 19, 459-464, 2001 [More information].

Yeom, S-H, Louie, J. and Daugulis, A.J., "The Use of Partitioning Bioreactors for the Treatment of High-Concentration Benzene Solutions," Can.J.Chem.Eng. 79, (5), 785-790, 2001.

Li, Z., Xiong, F., Lin, Q., d'Anjou, M., Daugulis, A.J., Yang, D.S.C., and Hew, C.L., "Low Temperature Increases the Yield of Biologically Active Herring Antifreeze Protein in Pichia pastoris," Protein Expression and Purification 21, 438-445, 2001 [More information].

Yeom, S-H, and Daugulis, A.J., "A Two-Phase Partitioning Bioreactor System for Treating Benzene-Contaminated Soil," Biotechnol Letters 23, 467-473, 2001 [More information].

Yeom, S.H, and Daugulis, A.J., "Benzene Degradation in a Two-Phase Partitioning Bioreactor by Alcaligenes xylosoxidans Y234," Process Biochemistry 36, 765-772, 2001 [More information].

Yeom, S.H. and Daugulis, A.J., "Development of a Novel Bioreactor System for the Treatment of Gaseous Benzene," Biotechnol. Bioeng. 72, 156-165, 2001 [More information].

d'Anjou, M.C., and Daugulis, A.J., "A Rational Approach to Improving Productivity in Recombinant Pichia pastoris Fermentation," Biotechnol.Bioeng. 72, 1-11, 2001 [More information].

Patents

Daugulis, A.J. and Collins, D.L., "Process for Biodegradation of a Xenobiotic," US Patent No. 6,284,523, September, 2001.


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