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Influence of Nutrient Supply on Tissue Formation

There is increasing evidence that the supply of nutrients is a limiting factor during in vitro tissue development. As well, in certain connective tissues, a decline in the nutrient supply has been implicated in tissue degeneration in vivo. This study is directed at the interplay between different energy metabolism pathways and the synthesis of extracellular matrix macromolecules by various types of connective tissue cells (chondrocytes, fibroblasts, etc.).